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Author for Correspondence: Jouni Uitto, MD, Ph.D. Department of Dermatology and Cutaneous Biology Jefferson Medical College 233 South 10 Street, Suite 450 BLSB Philadelphia, PA 19107, U.S.A. Tel: 215-503-5785 Fax: 215-503-5788 E-mail: [email protected] © 2013. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.